ABSTRACT
Objective To analyze the epidemiological situation of human intestinal nematode infections in Nanjing City from 2006 to 2015,so as to provide the reference for formulating prevention and control measures. Methods The surveillance data of human intestinal nematode infections in Nanjing City from 2006 to 2015 were collected and analyzed statistically. Results From 2006 to 2015,98804 person-times of residents were surveyed in Nanjing City,and 465 person-times of residents were de-tected with intestinal nematode infections. The highest infection rate was in 2006(1.97%),and the lowest in 2013 and 2015 (both 0.05%). Moreover,the positive rate of human intestinal nematode infections showed a significantly declining trend in total (χ2=552.19,P<0.001). Meanwhile,the numbers of Ascaris lumbricoides,hookworm and Trichuris trichura cases were 329, 98 and 25 respectively,and the infection rates were 0.33%,0.10%and 0.03%respectively. Among them,443 cases had mild infection intensity (98.66%). There were 462 cases of single-infection (99.35%),and 3 of co-infection of two parasites (0.65%). From 2006 to 2015,92539 person-times of children under 12 years old were surveyed for Enterobius vermicularis in-fection and 352 cases were detected with E. vermicularis infection. Moreover,the positive rate showed a significantly decreasing trend in total(χ2=147.94,P<0.001). Conclusions The control effect of human intestinal nematode infections in Nanjing City is remarkable. However,the surveillance and health education in key groups still should be strengthened,and the preven-tion and control programs should be adjusted promptly to further consolidating the effectiveness of intestinal nematode disease prevention and control.
ABSTRACT
Objective: To investigate the synergistic antibacterial effect of Callicarpa nudiflora associated with Vancomycin Hydrochloride on the pneumonia model rats infected by methicillin-resistant staphylococcus aureus (MRSA), and to provide a safer and more effective treatment of clinical ideas for the treatment of infections caused by MRSA. Methods: Totally 80 NIH female rats were randomly divided into eight groups, ten rats as the control group, and 200 μL MRSA (1 × 108 CFU/ mL) bacteria was dropped in the left nasal cavity of the remaining rats to produce infected animal model. The administration with drug respectively by group was continued for 10 d. The common state including activity and intake of water and food were observed and noted. After administration for 10 d, the count of leucocyte, microbial load, and histopathological change of lung were observed. Results: Compared with the model group, the absolute value of leucocyte and microbial load of association of C. nudiflora and Vancomycin Hydrochloride were reduced signicantly (P < 0.05). The pathological damage alleviated significantly. Conclusion: Association of C. nudiflora and Vancomycin Hydrochloride has the synergistic antibacterial effect towards MRSA, which can improve the curative effect of antibiotics and shorten the period of treatment.